There remained one significant problem.

还有一个非常重要的问题。

《牛津词典》

This is a significant problem for him.

这对他是个严重的问题。

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“Having only one planet makes this a rather significant problem, ” says Gilding.

“然而我们只有一个地球，这使得问题更加明朗化，”吉尔丁这样说道。

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Despite eradication efforts, malaria remains a significant health problem in Brazil.

VOA: standard.2010.06.17

They wait until they are facing a significant problem before they ask for our assistance.

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Counterfeit medicine is a significant problem in developing countries, causing more than 700, 000 deaths each year.

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Now when I first read all of this I thought there was a significant problem.

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